SCOPE vs STOP
- Outcomes: Prolactin, hPL, GH2, Insulin, HOME-IR, glucose (all outcomes log-transformed)
- Independent variables: Study, GDM_new, BMI, Ethnicity (Caucasian/non-Caucasian), smoking (yes/no), GA at sampling
- Model fitted: LME or GEE model
log(hormones) ~ Study + GA at sampling + Study:GA at sampling
Random intercepts for Study ID and Plate
Global tests
Type III ANOVA on main and interaction effects, and LM model summaries.
Prolactin
|
|
Chisq
|
Df
|
Pr(>Chisq)
|
|
|
(Intercept)
|
186.2873571
|
1
|
<0.0001
|
***
|
|
Study
|
2.3744735
|
1
|
0.1
|
ns
|
|
GDM_new
|
0.8352147
|
1
|
0.4
|
ns
|
|
BMI
|
2.3632920
|
1
|
0.1
|
ns
|
|
Ethnicity_cauc
|
89.8462847
|
1
|
<0.0001
|
***
|
|
f10c_any_cig_1st_vst
|
27.6014746
|
1
|
<0.0001
|
***
|
|
GA_samp
|
145.4047280
|
1
|
<0.0001
|
***
|
|
Study:GDM_new
|
2.0357209
|
1
|
0.2
|
ns
|
HPL
|
|
Chisq
|
Df
|
Pr(>Chisq)
|
|
|
(Intercept)
|
114.7698430
|
1
|
<0.0001
|
***
|
|
Study
|
7.2736070
|
1
|
0.007
|
**
|
|
GDM_new
|
1.2866802
|
1
|
0.3
|
ns
|
|
BMI
|
122.0690428
|
1
|
<0.0001
|
***
|
|
Ethnicity_cauc
|
2.9326031
|
1
|
0.09
|
ns
|
|
f10c_any_cig_1st_vst
|
0.2523666
|
1
|
0.6
|
ns
|
|
GA_samp
|
2038.4734597
|
1
|
<0.0001
|
***
|
|
Study:GDM_new
|
1.9535696
|
1
|
0.2
|
ns
|
GH2
|
|
Chisq
|
Df
|
Pr(>Chisq)
|
|
|
(Intercept)
|
222.6039862
|
1
|
<0.0001
|
***
|
|
Study
|
0.8028006
|
1
|
0.4
|
ns
|
|
GDM_new
|
1.2852257
|
1
|
0.3
|
ns
|
|
BMI
|
27.8356406
|
1
|
<0.0001
|
***
|
|
Ethnicity_cauc
|
0.6462443
|
1
|
0.4
|
ns
|
|
f10c_any_cig_1st_vst
|
0.4132299
|
1
|
0.5
|
ns
|
|
GA_samp
|
862.5535317
|
1
|
<0.0001
|
***
|
|
Study:GDM_new
|
3.4900314
|
1
|
0.06
|
ns
|
Insulin
|
|
model term
|
df1
|
df2
|
F.ratio
|
Chisq
|
p.value
|
|
|
1
|
Study
|
1
|
Inf
|
21.941
|
21.941
|
<0.0001
|
***
|
|
3
|
GDM_new
|
1
|
Inf
|
32.023
|
32.023
|
<0.0001
|
***
|
|
4
|
BMI
|
1
|
Inf
|
228.774
|
228.774
|
<0.0001
|
***
|
|
5
|
Ethnicity_cauc
|
1
|
Inf
|
16.948
|
16.948
|
<0.0001
|
***
|
|
6
|
f10c_any_cig_1st_vst
|
1
|
Inf
|
0.127
|
0.127
|
0.7
|
ns
|
|
7
|
GA_samp
|
1
|
Inf
|
0.547
|
0.547
|
0.5
|
ns
|
|
2
|
Study:GDM_new
|
1
|
Inf
|
4.128
|
4.128
|
0.04
|
*
|
HOMA.IR
|
|
model term
|
df1
|
df2
|
F.ratio
|
Chisq
|
p.value
|
|
|
1
|
Study
|
1
|
Inf
|
35.890
|
35.890
|
<0.0001
|
***
|
|
3
|
GDM_new
|
1
|
Inf
|
29.826
|
29.826
|
<0.0001
|
***
|
|
4
|
BMI
|
1
|
Inf
|
225.782
|
225.782
|
<0.0001
|
***
|
|
5
|
Ethnicity_cauc
|
1
|
Inf
|
17.023
|
17.023
|
<0.0001
|
***
|
|
6
|
f10c_any_cig_1st_vst
|
1
|
Inf
|
0.075
|
0.075
|
0.8
|
ns
|
|
7
|
GA_samp
|
1
|
Inf
|
0.242
|
0.242
|
0.6
|
ns
|
|
2
|
Study:GDM_new
|
1
|
Inf
|
4.391
|
4.391
|
0.04
|
*
|
GLUC3_mmol.L
|
|
model term
|
df1
|
df2
|
F.ratio
|
Chisq
|
p.value
|
|
|
1
|
Study
|
1
|
Inf
|
54.379
|
54.379
|
<0.0001
|
***
|
|
3
|
GDM_new
|
1
|
Inf
|
3.763
|
3.763
|
0.05
|
ns
|
|
4
|
BMI
|
1
|
Inf
|
8.487
|
8.487
|
0.004
|
**
|
|
5
|
Ethnicity_cauc
|
1
|
Inf
|
1.174
|
1.174
|
0.3
|
ns
|
|
6
|
f10c_any_cig_1st_vst
|
1
|
Inf
|
0.002
|
0.002
|
1.0
|
ns
|
|
7
|
GA_samp
|
1
|
Inf
|
0.289
|
0.289
|
0.6
|
ns
|
|
2
|
Study:GDM_new
|
1
|
Inf
|
1.683
|
1.683
|
0.2
|
ns
|
Model Summary
Ratio of Geometric means (95% CI)
Prolactin
|
Var
|
Effect
|
P
|
|
(Intercept)
|
2.88 (2.47, 3.30)
|
<0.0001
|
|
StudySTOP
|
-0.10 (-0.22, 0.03)
|
0.12
|
|
GDM_newGDM
|
-0.09 (-0.29, 0.11)
|
0.36
|
|
BMI
|
-0.00 (-0.01, 0.00)
|
0.12
|
|
Ethnicity_caucNo
|
0.46 (0.37, 0.56)
|
<0.0001
|
|
f10c_any_cig_1st_vstYes
|
-0.23 (-0.32, -0.14)
|
<0.0001
|
|
GA_samp
|
0.14 (0.12, 0.16)
|
<0.0001
|
|
StudySTOP:GDM_newGDM
|
0.16 (-0.06, 0.37)
|
0.15
|
HPL
|
Var
|
Effect
|
P
|
|
(Intercept)
|
1.18 (0.96, 1.39)
|
<0.0001
|
|
StudySTOP
|
0.09 (0.02, 0.15)
|
0.007
|
|
GDM_newGDM
|
-0.06 (-0.15, 0.04)
|
0.26
|
|
BMI
|
-0.02 (-0.02, -0.01)
|
<0.0001
|
|
Ethnicity_caucNo
|
0.05 (-0.01, 0.10)
|
0.09
|
|
f10c_any_cig_1st_vstYes
|
0.01 (-0.03, 0.06)
|
0.62
|
|
GA_samp
|
0.29 (0.27, 0.30)
|
<0.0001
|
|
StudySTOP:GDM_newGDM
|
0.08 (-0.03, 0.19)
|
0.16
|
GH2
|
Var
|
Effect
|
P
|
|
(Intercept)
|
-2.25 (-2.54, -1.95)
|
<0.0001
|
|
StudySTOP
|
-0.04 (-0.13, 0.05)
|
0.37
|
|
GDM_newGDM
|
-0.09 (-0.23, 0.06)
|
0.26
|
|
BMI
|
-0.01 (-0.01, -0.01)
|
<0.0001
|
|
Ethnicity_caucNo
|
0.03 (-0.04, 0.10)
|
0.42
|
|
f10c_any_cig_1st_vstYes
|
0.02 (-0.04, 0.09)
|
0.52
|
|
GA_samp
|
0.26 (0.24, 0.27)
|
<0.0001
|
|
StudySTOP:GDM_newGDM
|
0.16 (-0.01, 0.32)
|
0.06
|
Insulin
|
Var
|
Effect
|
P
|
|
(Intercept)
|
1.07 (0.54, 1.60)
|
<0.0001
|
|
StudySTOP
|
-0.31 (-0.48, -0.14)
|
0.0003
|
|
GDM_newGDM
|
0.55 (0.31, 0.79)
|
<0.0001
|
|
BMI
|
0.05 (0.05, 0.06)
|
<0.0001
|
|
Ethnicity_caucNo
|
0.30 (0.16, 0.45)
|
<0.0001
|
|
f10c_any_cig_1st_vstYes
|
-0.02 (-0.15, 0.10)
|
0.72
|
|
GA_samp
|
0.01 (-0.02, 0.04)
|
0.46
|
|
StudySTOP:GDM_newGDM
|
-0.28 (-0.55, -0.01)
|
0.04
|
HOMA.IR
|
Var
|
Effect
|
P
|
|
(Intercept)
|
-0.38 (-0.94, 0.17)
|
0.18
|
|
StudySTOP
|
-0.46 (-0.64, -0.28)
|
<0.0001
|
|
GDM_newGDM
|
0.62 (0.34, 0.90)
|
<0.0001
|
|
BMI
|
0.06 (0.05, 0.06)
|
<0.0001
|
|
Ethnicity_caucNo
|
0.32 (0.17, 0.47)
|
<0.0001
|
|
f10c_any_cig_1st_vstYes
|
-0.02 (-0.15, 0.12)
|
0.78
|
|
GA_samp
|
0.01 (-0.03, 0.04)
|
0.62
|
|
StudySTOP:GDM_newGDM
|
-0.33 (-0.64, -0.02)
|
0.04
|
GLUC3_mmol.L
|
Var
|
Effect
|
P
|
|
(Intercept)
|
1.65 (1.53, 1.76)
|
<0.0001
|
|
StudySTOP
|
-0.14 (-0.18, -0.11)
|
<0.0001
|
|
GDM_newGDM
|
0.09 (-0.02, 0.20)
|
0.09
|
|
BMI
|
0.00 (0.00, 0.00)
|
0.004
|
|
Ethnicity_caucNo
|
0.01 (-0.01, 0.04)
|
0.28
|
|
f10c_any_cig_1st_vstYes
|
0.00 (-0.03, 0.03)
|
0.97
|
|
GA_samp
|
-0.00 (-0.01, 0.01)
|
0.59
|
|
StudySTOP:GDM_newGDM
|
-0.07 (-0.18, 0.04)
|
0.19
|
Diagnostics
Model diagnositcs.
Diagnositcs for PRL (ng/ml)
Diagnositcs for hPL (μg/ml)
Diagnositcs for GH2 (ng/ml)
Diagnositcs for Insulin (uU/L)
Diagnositcs for HOMA-IR
Diagnositcs for Glucose (mmol/L)
Results
Estimated means
Estimated marginal means (or adjusted means) adjusted for GA at sampling, BMI, ethnicity and smoking.
Prolactin
|
Study
|
GDM_new
|
response
|
SE
|
df
|
lower.CL
|
upper.CL
|
|
SCOPE
|
Uncomplicated
|
109.56262
|
9.305789
|
118.0932
|
92.60115
|
129.6309
|
|
STOP
|
Uncomplicated
|
99.54973
|
7.854561
|
88.1698
|
85.10303
|
116.4488
|
|
SCOPE
|
GDM
|
99.89480
|
12.472731
|
445.2661
|
78.15798
|
127.6769
|
|
STOP
|
GDM
|
106.18421
|
9.423807
|
137.5003
|
89.09337
|
126.5536
|
HPL
|
Study
|
GDM_new
|
response
|
SE
|
df
|
lower.CL
|
upper.CL
|
|
SCOPE
|
Uncomplicated
|
89.30254
|
2.778154
|
308.6675
|
83.99997
|
94.93983
|
|
STOP
|
Uncomplicated
|
97.65092
|
2.612781
|
168.6963
|
92.62681
|
102.94753
|
|
SCOPE
|
GDM
|
84.38702
|
4.573660
|
701.9769
|
75.86859
|
93.86189
|
|
STOP
|
GDM
|
99.76871
|
3.433946
|
352.9937
|
93.23866
|
106.75611
|
GH2
|
Study
|
GDM_new
|
response
|
SE
|
df
|
lower.CL
|
upper.CL
|
|
SCOPE
|
Uncomplicated
|
2.304031
|
0.0891074
|
713.3547
|
2.135564
|
2.485789
|
|
STOP
|
Uncomplicated
|
2.212179
|
0.0685501
|
355.4472
|
2.081390
|
2.351187
|
|
SCOPE
|
GDM
|
2.115925
|
0.1647247
|
1117.7141
|
1.816195
|
2.465121
|
|
STOP
|
GDM
|
2.372943
|
0.1005954
|
556.9857
|
2.183353
|
2.578995
|
Insulin
|
Study
|
GDM_new
|
response
|
SE
|
df
|
asymp.LCL
|
asymp.UCL
|
|
SCOPE
|
Uncomplicated
|
16.35528
|
1.1990823
|
Inf
|
14.16616
|
18.88267
|
|
STOP
|
Uncomplicated
|
12.00574
|
0.6450841
|
Inf
|
10.80569
|
13.33905
|
|
SCOPE
|
GDM
|
28.32869
|
3.5746105
|
Inf
|
22.12173
|
36.27722
|
|
STOP
|
GDM
|
15.68505
|
1.1803706
|
Inf
|
13.53409
|
18.17785
|
HOMA.IR
|
Study
|
GDM_new
|
response
|
SE
|
df
|
asymp.LCL
|
asymp.UCL
|
|
SCOPE
|
Uncomplicated
|
4.011720
|
0.3145035
|
Inf
|
3.440326
|
4.678014
|
|
STOP
|
Uncomplicated
|
2.526515
|
0.1430172
|
Inf
|
2.261197
|
2.822965
|
|
SCOPE
|
GDM
|
7.432129
|
1.0767853
|
Inf
|
5.594857
|
9.872734
|
|
STOP
|
GDM
|
3.354657
|
0.2712629
|
Inf
|
2.862983
|
3.930770
|
GLUC3_mmol.L
|
Study
|
GDM_new
|
response
|
SE
|
df
|
asymp.LCL
|
asymp.UCL
|
|
SCOPE
|
Uncomplicated
|
5.467687
|
0.0818211
|
Inf
|
5.309650
|
5.630429
|
|
STOP
|
Uncomplicated
|
4.746897
|
0.0485391
|
Inf
|
4.652709
|
4.842992
|
|
SCOPE
|
GDM
|
6.005111
|
0.2972873
|
Inf
|
5.449814
|
6.616988
|
|
STOP
|
GDM
|
4.849296
|
0.0683255
|
Inf
|
4.717212
|
4.985078
|
Comparisons
Prolactin
|
contrast
|
ratio
|
SE
|
df
|
lower.CL
|
upper.CL
|
p.value
|
|
|
STOP/SCOPE (Uncomplicated)
|
0.909
|
0.057
|
1440.121
|
0.804
|
1.027
|
0.124
|
ns
|
|
STOP/SCOPE (GDM_new)
|
1.063
|
0.122
|
1271.507
|
0.849
|
1.330
|
0.594
|
ns
|
|
GDM_new/Uncomplicated (SCOPE)
|
0.912
|
0.092
|
1206.203
|
0.748
|
1.112
|
0.361
|
ns
|
|
GDM_new/Uncomplicated (STOP)
|
1.067
|
0.056
|
1412.722
|
0.963
|
1.182
|
0.217
|
ns
|
HPL
|
contrast
|
ratio
|
SE
|
df
|
lower.CL
|
upper.CL
|
p.value
|
|
|
STOP/SCOPE (Uncomplicated)
|
1.093
|
0.036
|
1449.240
|
1.025
|
1.167
|
0.007
|
**
|
|
STOP/SCOPE (GDM_new)
|
1.182
|
0.069
|
1046.878
|
1.054
|
1.326
|
0.004
|
**
|
|
GDM_new/Uncomplicated (SCOPE)
|
0.945
|
0.047
|
734.683
|
0.857
|
1.042
|
0.257
|
ns
|
|
GDM_new/Uncomplicated (STOP)
|
1.022
|
0.029
|
1437.110
|
0.966
|
1.081
|
0.454
|
ns
|
GH2
|
contrast
|
ratio
|
SE
|
df
|
lower.CL
|
upper.CL
|
p.value
|
|
|
STOP/SCOPE (Uncomplicated)
|
0.960
|
0.044
|
1294.983
|
0.878
|
1.050
|
0.370
|
ns
|
|
STOP/SCOPE (GDM_new)
|
1.121
|
0.097
|
1340.588
|
0.947
|
1.328
|
0.184
|
ns
|
|
GDM_new/Uncomplicated (SCOPE)
|
0.918
|
0.069
|
1260.805
|
0.793
|
1.064
|
0.257
|
ns
|
|
GDM_new/Uncomplicated (STOP)
|
1.073
|
0.043
|
1494.387
|
0.992
|
1.159
|
0.077
|
ns
|
Insulin
|
contrast
|
ratio
|
SE
|
df
|
asymp.LCL
|
asymp.UCL
|
p.value
|
|
|
STOP/SCOPE (Uncomplicated)
|
0.734
|
0.063
|
Inf
|
0.621
|
0.868
|
0.0003
|
***
|
|
STOP/SCOPE (GDM_new)
|
0.554
|
0.080
|
Inf
|
0.417
|
0.735
|
<0.0001
|
***
|
|
GDM_new/Uncomplicated (SCOPE)
|
1.732
|
0.211
|
Inf
|
1.364
|
2.199
|
<0.0001
|
***
|
|
GDM_new/Uncomplicated (STOP)
|
1.306
|
0.094
|
Inf
|
1.134
|
1.505
|
0.0002
|
***
|
HOMA.IR
|
contrast
|
ratio
|
SE
|
df
|
asymp.LCL
|
asymp.UCL
|
p.value
|
|
|
STOP/SCOPE (Uncomplicated)
|
0.630
|
0.057
|
Inf
|
0.527
|
0.752
|
<0.0001
|
***
|
|
STOP/SCOPE (GDM_new)
|
0.451
|
0.073
|
Inf
|
0.328
|
0.621
|
<0.0001
|
***
|
|
GDM_new/Uncomplicated (SCOPE)
|
1.853
|
0.264
|
Inf
|
1.402
|
2.448
|
<0.0001
|
***
|
|
GDM_new/Uncomplicated (STOP)
|
1.328
|
0.103
|
Inf
|
1.141
|
1.545
|
0.0002
|
***
|
GLUC3_mmol.L
|
contrast
|
ratio
|
SE
|
df
|
asymp.LCL
|
asymp.UCL
|
p.value
|
|
|
STOP/SCOPE (Uncomplicated)
|
0.868
|
0.016
|
Inf
|
0.838
|
0.899
|
<0.0001
|
***
|
|
STOP/SCOPE (GDM_new)
|
0.808
|
0.039
|
Inf
|
0.734
|
0.889
|
<0.0001
|
***
|
|
GDM_new/Uncomplicated (SCOPE)
|
1.098
|
0.061
|
Inf
|
0.984
|
1.225
|
0.093
|
ns
|
|
GDM_new/Uncomplicated (STOP)
|
1.022
|
0.014
|
Inf
|
0.994
|
1.050
|
0.132
|
ns
|
Comparisons by Timepoint
Prolactin
|
contrast
|
ratio
|
SE
|
df
|
lower.CL
|
upper.CL
|
p.value
|
|
|
STOP/SCOPE (Uncomplicated)|10wks
|
0.909
|
0.057
|
1440.121
|
0.804
|
1.027
|
0.124
|
ns
|
|
STOP/SCOPE (GDM_new)|10wks
|
1.063
|
0.122
|
1271.507
|
0.849
|
1.330
|
0.594
|
ns
|
|
GDM_new/Uncomplicated (SCOPE)|10wks
|
0.912
|
0.092
|
1206.203
|
0.748
|
1.112
|
0.361
|
ns
|
|
GDM_new/Uncomplicated (STOP)|10wks
|
1.067
|
0.056
|
1412.722
|
0.963
|
1.182
|
0.217
|
ns
|
|
STOP/SCOPE (Uncomplicated)|16wks
|
0.909
|
0.057
|
1440.121
|
0.804
|
1.027
|
0.124
|
ns
|
|
STOP/SCOPE (GDM_new)|16wks
|
1.063
|
0.122
|
1271.507
|
0.849
|
1.330
|
0.594
|
ns
|
|
GDM_new/Uncomplicated (SCOPE)|16wks
|
0.912
|
0.092
|
1206.203
|
0.748
|
1.112
|
0.361
|
ns
|
|
GDM_new/Uncomplicated (STOP)|16wks
|
1.067
|
0.056
|
1412.722
|
0.963
|
1.182
|
0.217
|
ns
|
|
16wks/10wks (Uncomplicated)|SCOPE
|
2.320
|
0.162
|
1435.177
|
2.023
|
2.660
|
<0.0001
|
***
|
|
16wks/10wks (GDM_new)|SCOPE
|
2.320
|
0.162
|
1435.177
|
2.023
|
2.660
|
<0.0001
|
***
|
|
16wks/10wks (Uncomplicated)|STOP
|
2.320
|
0.162
|
1435.177
|
2.023
|
2.660
|
<0.0001
|
***
|
|
16wks/10wks (GDM_new)|STOP
|
2.320
|
0.162
|
1435.177
|
2.023
|
2.660
|
<0.0001
|
***
|
HPL
|
contrast
|
ratio
|
SE
|
df
|
lower.CL
|
upper.CL
|
p.value
|
|
|
STOP/SCOPE (Uncomplicated)|10wks
|
1.093
|
0.036
|
1449.240
|
1.025
|
1.167
|
0.007
|
**
|
|
STOP/SCOPE (GDM_new)|10wks
|
1.182
|
0.069
|
1046.878
|
1.054
|
1.326
|
0.004
|
**
|
|
GDM_new/Uncomplicated (SCOPE)|10wks
|
0.945
|
0.047
|
734.683
|
0.857
|
1.042
|
0.257
|
ns
|
|
GDM_new/Uncomplicated (STOP)|10wks
|
1.022
|
0.029
|
1437.110
|
0.966
|
1.081
|
0.454
|
ns
|
|
STOP/SCOPE (Uncomplicated)|16wks
|
1.093
|
0.036
|
1449.240
|
1.025
|
1.167
|
0.007
|
**
|
|
STOP/SCOPE (GDM_new)|16wks
|
1.182
|
0.069
|
1046.878
|
1.054
|
1.326
|
0.004
|
**
|
|
GDM_new/Uncomplicated (SCOPE)|16wks
|
0.945
|
0.047
|
734.683
|
0.857
|
1.042
|
0.257
|
ns
|
|
GDM_new/Uncomplicated (STOP)|16wks
|
1.022
|
0.029
|
1437.110
|
0.966
|
1.081
|
0.454
|
ns
|
|
16wks/10wks (Uncomplicated)|SCOPE
|
5.574
|
0.212
|
1454.688
|
5.173
|
6.006
|
<0.0001
|
***
|
|
16wks/10wks (GDM_new)|SCOPE
|
5.574
|
0.212
|
1454.688
|
5.173
|
6.006
|
<0.0001
|
***
|
|
16wks/10wks (Uncomplicated)|STOP
|
5.574
|
0.212
|
1454.688
|
5.173
|
6.006
|
<0.0001
|
***
|
|
16wks/10wks (GDM_new)|STOP
|
5.574
|
0.212
|
1454.688
|
5.173
|
6.006
|
<0.0001
|
***
|
GH2
|
contrast
|
ratio
|
SE
|
df
|
lower.CL
|
upper.CL
|
p.value
|
|
|
STOP/SCOPE (Uncomplicated)|10wks
|
0.960
|
0.044
|
1294.983
|
0.878
|
1.050
|
0.370
|
ns
|
|
STOP/SCOPE (GDM_new)|10wks
|
1.121
|
0.097
|
1340.588
|
0.947
|
1.328
|
0.184
|
ns
|
|
GDM_new/Uncomplicated (SCOPE)|10wks
|
0.918
|
0.069
|
1260.805
|
0.793
|
1.064
|
0.257
|
ns
|
|
GDM_new/Uncomplicated (STOP)|10wks
|
1.073
|
0.043
|
1494.387
|
0.992
|
1.159
|
0.077
|
ns
|
|
STOP/SCOPE (Uncomplicated)|16wks
|
0.960
|
0.044
|
1294.983
|
0.878
|
1.050
|
0.370
|
ns
|
|
STOP/SCOPE (GDM_new)|16wks
|
1.121
|
0.097
|
1340.588
|
0.947
|
1.328
|
0.184
|
ns
|
|
GDM_new/Uncomplicated (SCOPE)|16wks
|
0.918
|
0.069
|
1260.805
|
0.793
|
1.064
|
0.257
|
ns
|
|
GDM_new/Uncomplicated (STOP)|16wks
|
1.073
|
0.043
|
1494.387
|
0.992
|
1.159
|
0.077
|
ns
|
|
16wks/10wks (Uncomplicated)|SCOPE
|
4.671
|
0.245
|
1432.164
|
4.214
|
5.177
|
<0.0001
|
***
|
|
16wks/10wks (GDM_new)|SCOPE
|
4.671
|
0.245
|
1432.164
|
4.214
|
5.177
|
<0.0001
|
***
|
|
16wks/10wks (Uncomplicated)|STOP
|
4.671
|
0.245
|
1432.164
|
4.214
|
5.177
|
<0.0001
|
***
|
|
16wks/10wks (GDM_new)|STOP
|
4.671
|
0.245
|
1432.164
|
4.214
|
5.177
|
<0.0001
|
***
|
Insulin
|
contrast
|
ratio
|
SE
|
df
|
asymp.LCL
|
asymp.UCL
|
p.value
|
|
|
STOP/SCOPE (Uncomplicated)|10wks
|
0.734
|
0.063
|
Inf
|
0.621
|
0.868
|
0.0003
|
***
|
|
STOP/SCOPE (GDM_new)|10wks
|
0.554
|
0.080
|
Inf
|
0.417
|
0.735
|
<0.0001
|
***
|
|
GDM_new/Uncomplicated (SCOPE)|10wks
|
1.732
|
0.211
|
Inf
|
1.364
|
2.199
|
<0.0001
|
***
|
|
GDM_new/Uncomplicated (STOP)|10wks
|
1.306
|
0.094
|
Inf
|
1.134
|
1.505
|
0.0002
|
***
|
|
STOP/SCOPE (Uncomplicated)|16wks
|
0.734
|
0.063
|
Inf
|
0.621
|
0.868
|
0.0003
|
***
|
|
STOP/SCOPE (GDM_new)|16wks
|
0.554
|
0.080
|
Inf
|
0.417
|
0.735
|
<0.0001
|
***
|
|
GDM_new/Uncomplicated (SCOPE)|16wks
|
1.732
|
0.211
|
Inf
|
1.364
|
2.199
|
<0.0001
|
***
|
|
GDM_new/Uncomplicated (STOP)|16wks
|
1.306
|
0.094
|
Inf
|
1.134
|
1.505
|
0.0002
|
***
|
|
16wks/10wks (Uncomplicated)|SCOPE
|
1.075
|
0.105
|
Inf
|
0.887
|
1.303
|
0.460
|
ns
|
|
16wks/10wks (GDM_new)|SCOPE
|
1.075
|
0.105
|
Inf
|
0.887
|
1.303
|
0.460
|
ns
|
|
16wks/10wks (Uncomplicated)|STOP
|
1.075
|
0.105
|
Inf
|
0.887
|
1.303
|
0.460
|
ns
|
|
16wks/10wks (GDM_new)|STOP
|
1.075
|
0.105
|
Inf
|
0.887
|
1.303
|
0.460
|
ns
|
HOMA.IR
|
contrast
|
ratio
|
SE
|
df
|
asymp.LCL
|
asymp.UCL
|
p.value
|
|
|
STOP/SCOPE (Uncomplicated)|10wks
|
0.630
|
0.057
|
Inf
|
0.527
|
0.752
|
<0.0001
|
***
|
|
STOP/SCOPE (GDM_new)|10wks
|
0.451
|
0.073
|
Inf
|
0.328
|
0.621
|
<0.0001
|
***
|
|
GDM_new/Uncomplicated (SCOPE)|10wks
|
1.853
|
0.264
|
Inf
|
1.402
|
2.448
|
<0.0001
|
***
|
|
GDM_new/Uncomplicated (STOP)|10wks
|
1.328
|
0.103
|
Inf
|
1.141
|
1.545
|
0.0002
|
***
|
|
STOP/SCOPE (Uncomplicated)|16wks
|
0.630
|
0.057
|
Inf
|
0.527
|
0.752
|
<0.0001
|
***
|
|
STOP/SCOPE (GDM_new)|16wks
|
0.451
|
0.073
|
Inf
|
0.328
|
0.621
|
<0.0001
|
***
|
|
GDM_new/Uncomplicated (SCOPE)|16wks
|
1.853
|
0.264
|
Inf
|
1.402
|
2.448
|
<0.0001
|
***
|
|
GDM_new/Uncomplicated (STOP)|16wks
|
1.328
|
0.103
|
Inf
|
1.141
|
1.545
|
0.0002
|
***
|
|
16wks/10wks (Uncomplicated)|SCOPE
|
1.052
|
0.109
|
Inf
|
0.859
|
1.289
|
0.623
|
ns
|
|
16wks/10wks (GDM_new)|SCOPE
|
1.052
|
0.109
|
Inf
|
0.859
|
1.289
|
0.623
|
ns
|
|
16wks/10wks (Uncomplicated)|STOP
|
1.052
|
0.109
|
Inf
|
0.859
|
1.289
|
0.623
|
ns
|
|
16wks/10wks (GDM_new)|STOP
|
1.052
|
0.109
|
Inf
|
0.859
|
1.289
|
0.623
|
ns
|
GLUC3_mmol.L
|
contrast
|
ratio
|
SE
|
df
|
asymp.LCL
|
asymp.UCL
|
p.value
|
|
|
STOP/SCOPE (Uncomplicated)|10wks
|
0.868
|
0.016
|
Inf
|
0.838
|
0.899
|
<0.0001
|
***
|
|
STOP/SCOPE (GDM_new)|10wks
|
0.808
|
0.039
|
Inf
|
0.734
|
0.889
|
<0.0001
|
***
|
|
GDM_new/Uncomplicated (SCOPE)|10wks
|
1.098
|
0.061
|
Inf
|
0.984
|
1.225
|
0.093
|
ns
|
|
GDM_new/Uncomplicated (STOP)|10wks
|
1.022
|
0.014
|
Inf
|
0.994
|
1.050
|
0.132
|
ns
|
|
STOP/SCOPE (Uncomplicated)|16wks
|
0.868
|
0.016
|
Inf
|
0.838
|
0.899
|
<0.0001
|
***
|
|
STOP/SCOPE (GDM_new)|16wks
|
0.808
|
0.039
|
Inf
|
0.734
|
0.889
|
<0.0001
|
***
|
|
GDM_new/Uncomplicated (SCOPE)|16wks
|
1.098
|
0.061
|
Inf
|
0.984
|
1.225
|
0.093
|
ns
|
|
GDM_new/Uncomplicated (STOP)|16wks
|
1.022
|
0.014
|
Inf
|
0.994
|
1.050
|
0.132
|
ns
|
|
16wks/10wks (Uncomplicated)|SCOPE
|
0.988
|
0.022
|
Inf
|
0.946
|
1.032
|
0.591
|
ns
|
|
16wks/10wks (GDM_new)|SCOPE
|
0.988
|
0.022
|
Inf
|
0.946
|
1.032
|
0.591
|
ns
|
|
16wks/10wks (Uncomplicated)|STOP
|
0.988
|
0.022
|
Inf
|
0.946
|
1.032
|
0.591
|
ns
|
|
16wks/10wks (GDM_new)|STOP
|
0.988
|
0.022
|
Inf
|
0.946
|
1.032
|
0.591
|
ns
|
